Sleep Deprivation May Lead to Weight Gain

Regularly getting less than 6 hours per day can alter appetite hormone levels.

By Scott Douglas , Runner’s World, Published November 27, 2012

People who regularly get less than six hours per day of sleep may have altered hormone levels that can lead to gaining weight,according to a research review published in the Journal of the Academy of Nutrition and Dietetics.

Researchers at Penn State University looked at studies that examined partial sleep deprivation and at least one bodily factor, such as levels of appetite hormones, or energy intake or expenditure. By “partial sleep deprivation” they meant studies on people reporting between four and six hours of sleep per day; less than that, the researchers decided, meant that the research subjects had a sleep-related problem different from simply not getting normal amounts of sleep.

Upon reviewing the collected data, the Penn State researchers found that, in people reporting partial sleep deprivation, levels of the hormone ghrelin were higher than normal, and levels of the hormone leptin were lower than normal. This finding is significant because ghrelin is associated with increased appetite–ghrelin levels tend to rise before eating and diminish after meals. In contrast, leptin is associated with feelings of satiety, and is normally released by adipose tissue after a meal. In other words, being partially sleep deprived can lead to feeling hungrier and less full than is warranted by your activity level.

The researchers also note that being partially sleep deprived potentially means being awake around food for more hours per day. In their review, the researchers found that when people eat more in these situations, they tend to eat high-fat and/or high-sugar foods; not many people cook up a serving of Brussels sprouts when working late into the night.

Another interesting finding was that, even for people who create a calorie deficit and therefore set themselves up for weight loss, partial sleep deprivation changes the nature of that weight loss. In the partial-deprivation state, the body loses less fat and more lean mass than it does in dieters who get enough sleep.

For more on the importance of adequate sleep and ways to attain it, Running Times article.

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The Benefits of a Killer Training Week

Super-loading your training once a month can pay off, a new study finds.

By Alex Hutchinson , Runner’s World, December 4, 2012

Many cross-country teams have annual training camps where they gather in some remote location for a few days to do crazy amounts of running at crazy intensities. This has always seemed to me to be sort of, well, crazy. But a recent study that Amby Burfoot mentioned on Twitter got me thinking.

The study is by researchers in Norway, published in the Scandinavian Journal of Medicine & Science in Sports, and it deals with what they call “block periodization.” The basic gist of their theory seems to be that if you’re trying to do everything at once in any given training week (i.e. easy miles, speed work, threshold work, etc.), you can’t put enough emphasis on any one of the elements to really push to a new level. This is a particular problem for already-well-trained endurance athletes, who have already taken all the “easy” adaptations that occur when you first start training.

So they set up a 12-week study with two groups of cyclists. One group did “traditional” training: two hard interval workouts per week, with mostly easy riding on the other days. The other group did a “block periodization” approach: for three weeks out of every four, they just did one hard interval workout per week (and easy riding on the other days); in the fourth week, they did five hard interval workouts! The experiment was designed so that the total training load of both groups had an equal total volume of hard and easy training (this was a flaw in previous studies of this idea) — the only difference was how that training was organized.

The results? Well, one obvious result was that the block periodization group reported very heavy legs every fourth week: the program wasn’t easy! But there was some payoff. Here are the individual changes in VO2 max for the two groups:

On average, the BP group gained 8.8% while the traditional group gained 3.7%. There were a whole bunch of other outcomes, including performance in an all-out 40-minute time trial: the general pattern seemed to be differences that weren’t quite statistically significant but leaned in favor of the block periodization group. Overall, the researchers characterize the new program as having a “moderate superior” effect compared to traditional training.

So is this the future? Well, maybe it’s more like the present — as I said at the top, the idea of having an occasional super-heavy week, often in conjunction with a training camp, is already well entrenched in a lot of groups. And more generally, lots of coaches recommend varying the intensity of training weeks, so that you have a regular cycle of up and down weeks. This study makes me think that it’s okay, and perhaps even beneficial, to push those periodic up weeks a bit harder than I might have thought prudent, even if you need to back off a little extra the following week. If nothing else, it’ll make you tougher (or injured)!

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Is Beer Good for Runners?

Beer Run!

A (somewhat) scientific look at how a postrun pint (or two) affects your favorite activity. Biggest surprise? It’s different for women.

By Christie Aschwanden, Runner’s World, January 5, 2012

I stood at the end of a ridiculously grueling trail amid the red cliffs of Western Colorado. Around me, runners enjoyed various cold, locally brewed beers wrapped in neoprene sleeves emblazoned with a sketch of the mountain we’d just torn up and down and the words “I survived the Summit and Plummet.” It was not yet 11 a.m.; we’d just finished one of the hardest five-mile runs in North America. We’d earned those beers. At least, that’s what we told ourselves.

It’s a common ritual among my running buddies. We run, then we drink. And we’re not alone. The outfit that organized today’s informal run often congregates at Grand Junction’s Kannah Creek Brewing Company following its weekly trail runs. Paonia’s Elegantly Attired Running Ladies, my women’s group, meets every Friday evening for a run that finishes at Revolution Brewing. And then there’s the famous Hash House Harriers, with chapters around the world, which calls itself a drinking club with a running problem. Among runners, coffee is perhaps the only beverage more popular than beer.

My friends and I often joke that we’re carbo-loading when we split a six pack together, but once in a while I wake up groggy and wonder: Could my drinking habit be hurting my running?

Turns out the research on alcohol and exercise is as herky-jerky as our culture’s attitude toward the bottle. Most early studies investigated alcohol’s potential as a performance enhancer. It seems ridiculous now, but during the 1904 Olympic Marathon, U.S. gold medalist Thomas Hicks was given a mixture of brandy, strychnine, and egg whites in an effort to gain a competitive edge. Many coaches then believed alcohol boosted energy.

In more recent years, not surprisingly, that belief has been largely disproved. One study on sprint-and middle-distance runners, for example, found that at most distances the more alcohol the athletes had, the slower they ran. Still, another study on male cyclists found that drinking the equivalent of two shots of hard liquor one hour before exercising didn’t give athletes any distinct advantages, nor did it significantly harm heart rate, blood pressure, or oxygen uptake. Even a hangover doesn’t seem to diminish your aerobic capacity—it just makes you feel lousy, so you underperform. But at the same time, there’s evidence to suggest that drinking after a workout might spoil recovery of muscle damage and reduce the amount of energy stored in muscles.

So what was all this conflicting information really telling me? Being a former scientist, I had my own theories about how drinking and running mix, and I couldn’t resist putting them to the test. The nearby Colorado Mesa University had just opened the Monfort Family Human Performance Research Lab, a state-of-the-art exercise-science facility that seemed like the perfect venue to explore alcohol’s effects on running performance. My friend Gig Leadbetter, Ph.D., coaches the school’s cross-country team and is an exercise scientist at the Monfort Lab. He’s also a home brewer and winemaker and, without any arm-twisting, agreed to put together a study for Runner’s World.

He decided to test whether drinking beer immediately following a hard run would sap performance the next day. Since men and women metabolize alcohol differently, he opted to test both and look for gender differences as well—something previous studies didn’t examine. Part one of the experiment—the Beer Run—was a 45-minute, early evening run at an intensity that would require tapping into muscle-fuel stores, immediately followed by a serving of beer. Part two—the Exhaustion Run—would take place the next morning and provide a measure of the recovery. On this run, volunteers would run at 80 percent of their max for as long as they could tolerate.

Researchers tested the volunteers twice, using two unnamed beers and without divulging their alcoholic content. In Round One some runners consumed regular alcoholic beer—Fat Tire Amber Ale—while others had a nonalcoholic beer, O’Doul’s Amber. (In Round Two, the beer options were reversed.) One would expect runners to run out of gas faster the morning after their Fat Tire run than they did the morning after drinking the O’Doul’s. Real beer might also make the Exhaustion Run feel more difficult. Finally, real beer might alter the amounts of fat and carbohydrates our muscles burned for fuel.

CHEERS TO SCIENCE!
We’d recruited five men and five women—myself included—ranging in age from 29 to 43, all moderate drinkers (defined as drinking less than the recommended daily limits of two drinks per day for men, one for women) and who ran at least 35 miles per week. At the orientation a week before the first Beer Run, Leadbetter explained the study before serving us Fat Tire beers. He was trying to get us to about .07 percent blood alcohol concentration (BAC), which is below the legal limit for driving under the influence. The hope was to simulate a “normal” amount of beer a runner might drink after a race or workout.

To figure out how many beers equaled “normal,” Leadbetter started the orientation with the government’s alcohol impairment chart, which estimates blood alcohol levels using body weight and alcohol percentages. Over the course of the next hour, everyone drank what the chart predicted would amount to .07 percent BAC. Because individual metabolism can vary, however, Leadbetter invited a couple of cops to give us Breathalyzer tests to ensure everyone got the right dose.

It’s a good thing he called for backup. The chart proved right on the mark for some, but was way off for others. It correctly predicted, for example, that 29-year-old Daniel Rohr needed to drink three and a half beers to reach .07. However, it led Bryan Whitt, a muscular 149 pounds, to drink almost three Fat Tires. As Whitt strode to the front of the room and faced the cop for his moment of truth, he didn’t seem at all impaired. But when he blew into the Breathalyzer, the number came up to .095 percent. The chart also wrongly limited a petite Cynthia Malleck to one 12-ounce beer, when she really needed almost two full bottles. By night’s end, as volunteers met their designated drivers, Leadbetter and his team knew exactly how much to pour.

Everyone reconvened the following Friday evening for the first Beer Run. We ran on treadmills for 45 minutes at a pace that felt steady, like tempo, but not overly strenuous. Then we gathered on the patio behind the lab and drank cold beer (or the placebo) and devoured plates of pasta and tomato sauce (carbs!).

The next morning, volunteers returned to the lab for the first Exhaustion Run, a task as grueling as it sounds. After we ran at a fast clip for as long as possible, researchers measured our heart rates and metabolic factors, such as oxygen consumption and carbon-dioxide production. Every three minutes, they asked us to rate how hard we were working.

My legs ached from the beginning, but I was determined to tough it out to 20 minutes. The treadmill’s timer was obscured, but by eyeballing a clock across the room, I could guesstimate my time. As I approached what I thought was 20 minutes, my will to continue faded and my perceived effort soared. My legs felt heavy and uncooperative, but was I truly exhausted? Well, no. My heart rate and breathing were fine. With Leadbetter and the other researchers cheering me on, I kept going until at 32 minutes and 23 seconds I finally called it quits.

I downed a bagel and orange juice from the breakfast buffet, and then went home to rest up for the next run. That evening, I hit the treadmill and the suds again. Though I’d spent the day napping, this second Beer Run felt harder than the first. By the time I stepped onto the treadmill for the second Exhaustion Run the next day, my legs and brain were shot. Still, I was determined to suffer as hard as I could in the name of science—this was no time to go soft. But I lasted only 27 minutes and 31 seconds, almost five minutes less than I had the day before.

GOOD FOR WOMEN, BAD FOR MEN?
Right after the second Exhaustion Run, I sat down with Leadbetter to review a few results. The first shock was personal: I had assumed my second Exhaustion Run was so poor because I had drunk the real beer the night before. Wrong! I had actually been served the placebo the previous evening. Surely my results were a fluke. Leadbetter sent all the data to Bob Pettitt, Ph.D., an exercise physiologist and statistics expert at Minnesota State, Mankato.

The time differences between the beer and placebo Exhaustion Runs varied considerably from individual to individual. But when Pettitt averaged together the time differences between the two runs, they evened out to a big fat zero. Why? “The women did better after beer, but the men canceled it out by doing worse,” says Leadbetter. The five women ran an average of 22 percent longer the morning after drinking Fat Tire, while the men ran 21 percent shorter.

Pettitt’s analysis showed that this gender difference was statistically significant. However, “concluding gender differences based on 10 subjects is a big leap,” he says. Leadbetter agrees, which is why he’s spent recent months studying a larger group of runners. “Obviously, women use and metabolize fuel sources differently than men,” says Leadbetter. “If we find the same effect in [later] studies, then it will be really exciting.”

Ratings of perceived exertion, on the other hand, showed no significant difference between the trials, implying that the runs didn’t feel any easier or harder after real beer versus placebo beer.

If moderate drinking has a negative impact on performance, it seems to be a modest one, says Leadbetter. But even without a definitive answer, the results offer some assurance to beer drinkers. For those who are running for pleasure, any effect is probably no big deal, he says. On the other hand, if beer turns out to help women and hurt men like this study implies, even a single percentage point difference could mean the difference between a merely solid run and a PR.

TO DRINK, OR NOT TO DRINK
Afterward, I called some of the volunteers to get their takes on their results. Daniel Rohr ran about 13 percent longer the morning after drinking O’Doul’s, but says he felt similar during both trials. “I actually slept better the night after I drank the alcohol,” he says. A few weeks after the study, he competed in the Warrior Dash, a race that involved an obstacle course and free beer at the finish.

Trail runner Cynthia Malleck ran 44 percent longer on her real beer Exhaustion Run than she did after drinking the placebo, but she attributes the difference to fatigue. Malleck received the real beer the first day, and by the time the second Exhaustion Run came around, she was toast. “As I was getting on that treadmill, I thought, I have to do this again?”

But Karah Levely-Rinaldi received the real deal on the second trial and posted her longest run to exhaustion the next morning. She wasn’t surprised she’d lasted 4.5 minutes longer after drinking the Fat Tire, compared with the O’Doul’s. Last fall, she set a half-marathon PR (1:36) the morning after a three-margarita dinner. “Alcohol doesn’t seem to have a negative impact on my performance,” the mother of four says nonchalantly.

Larry Brede quit sooner on the run to exhaustion the morning after the Fat Tire, but he’s not so sure it was because of the alcohol. (He had to drink four beers within the allotted hour to reach his BAC.) “I’d had a long day at work when I had the beer,” he says. “I was overall more tired.”

As for me, I wasn’t ready to give up on my theory, so I decided to jump off the wagon for a month. In spite of my results, I was still pretty sure that without a drop of beer or wine, I’d run faster, sleep better, and maybe even lose some weight. Instead, my speed stayed the same, I still tossed and turned at night, and I didn’t lose a pound. So much for the beer gut!

The outcome of my monthlong dry run didn’t surprise Brede. A few years back, he gave up alcohol for four months while attempting to qualify for Boston. “I’d run a 3:28, and I needed to get under 3:10,” he says. “I ended up running a 3:25, and I decided it wasn’t worth it.” Eight months later, after resuming his beer drinking, he ran a 3:08. “I believe drinking is pretty independent of how well you’re trained and how well you’re eating.”

I agree. While I was disappointed to reap no benefits from giving up alcohol, the project proved that my drinking wasn’t causing me harm. I’d answered my question, and that’s worth celebrating.

 

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Teen Sleep Problems

By SUE SHELLENBARGER, Wall Street Journal, November 27, 2012

Q: Regarding your column on teen sleep problems, did adolescents in the past have less difficulty falling asleep? It seems that children raised on farms would have been more physically active, in addition to lacking the mobile devices and social-networking opportunities that keep teens awake today. —M.F., White Rock, British Columbia

A: The average teenager’s reduced physical exercise is one factor, but changes in teens’ exposure to bright light may be a bigger influence, says Mary Carskadon, a professor of psychiatry and human behavior at Brown University’s Alpert Medical School. All teens undergo a delay in the onset of sleepiness at puberty, when the body’s release of the sleep-inducing hormone melatonin shifts later by about 1.5 hours. The timing of day-to-day light exposure can either add to the delay, or offset it, Dr. Carskadon says. “Outdoor light has enormous effects on our behavior and timing,” and teens in a more agrarian past were more likely to be outdoors working early in bright, natural morning light. That early arousal helped offset hormonal changes, moving their bodies’ falling-asleep time a bit earlier.

Today’s adolescents, who often start school before dawn and stay indoors much of the day, typically have less exposure to early daylight. This makes them more sensitive to any bright light at night, says Dr. Carskadon, a leading sleep researcher. Their increased late-evening exposure to computer and other screens, as well as other light sources, pushes their sleep clocks later.

—Email sue.shellenbarger@wsj.com

 

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Study Finds Multivitamins Don’t Cut Risk of Heart Attack

By JENNIFER CORBETT DOOREN , Wall Street Journal, November 5, 2012

Taking a daily multivitamin didn’t cut the risk of heart attack and stroke in a study that followed more than 14,500 men for over a decade.

There was a small reduction in cancer risk, according to results from the study released in October.

The trial, called the Physicians Health Study II and partly funded by the National Institutes of Health, is the largest to look at health outcomes and multivitamins. The new findings were presented Monday at the American Heart Association annual meeting and published online in the Journal of the American Medical Association.

More than half of Americans take a vitamin or supplement on a regular basis, and about a third take a daily multivitamin.

The study looked at whether taking a common multivitamin—in this case Pfizer Inc.’s  Centrum Silver—can prevent disease compared with taking a placebo or sham vitamin. In addition to cancer and heart disease, researchers also looked at whether multivitamin use affected cognitive decline and eye disease. Information on cognitive decline and eye health has yet to be released. Pfizer provided the vitamins used in the study.

“Many people take vitamins as a crutch,” said Howard Sesso, one of the authors of the study and an associate professor at Harvard Medical School and Brigham and Women’s Hospital, in Boston. “There’s no substitute for a heart-healthy diet and exercise,” he said.

“One thing worth noting is these physicians were quite healthy,” Dr. Sesso added. “A lot of them exercised and most had pretty good diets”—which make it harder to measure the added benefit of a multivitamin.

Many doctors recommend multivitamins, and the supplements are strongly advised for certain groups like pregnant women.

Duffy MacKay, vice president for scientific affairs at the Council for Responsible Nutrition, a Washington, D.C., trade group for supplement makers, says vitamins combined with other “healthy habits” can be a “basic and affordable insurance policy for overall wellness.” He added, “No one should expect the multivitamin to wipe out all diseases known to man.”

The study enrolled 14,641 male U.S. physicians, ages 50 and older when the study began. More than 700 had heart disease at the start. Half received a multivitamin. The other half took placebos that looked like the real vitamins. Vitamins and placebo pills were dispensed in prefilled monthly packages so compliance could be measured.

Researchers followed the participants for more than 11 years, measuring cardiovascular events including heart attack and stroke, and death from a cardiovascular-related cause. There were 1,732 major cardiovascular events and 2,757 deaths during the study.

Researchers said event rates were mostly similar between treatment groups, suggesting multivitamins didn’t influence cardiovascular disease. There were slightly fewer heart attack-related deaths in the vitamin group, which might be attributed to chance, Dr. Sesso said.

Dariush Mozaffarian, associate professor at Harvard School of Public Health and a cardiologist who wasn’t involved in the study, says he worries that many people take vitamins as a “quick fix.” “The danger of taking a multivitamin leads you to think [you] don’t need to do the other lifestyle things that are important,” he said.

Write to Jennifer Corbett Dooren at jennifer.corbett-dooren@dowjones.com

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